I have a massive squirrel problem where I live, right now my balcony container gardening consists of mainly ipomeas and hot peppers, because they destroy everything else I've tried in the last 4 springs... squirrels mostly ignore the hot peppers, if I combine the two in the same pot....considering the toxicity of ipomeas, does it change the chemistry of the hot peppers?
🤔🤔🤔🤔🤔🤔

Growing these plants in the same container would be fine if it is big enough. There wouldn't be any transference of toxicity.

Ipomoea genus includes sweet potatoes. What kind are you considering? The gorgeous I. alba in your pic? I've not seen discussions about it being toxic but anything not widely considered edible should be assumed to be terrible-tasting at best, indigestible or dangerous to some degree at worst. Using sweet potato & "regular" potatoes as example, the tubers are edible but the leaves should not be eaten. Many plants are that way - parts are edible but the other parts should not be eaten.

Squirrels can be kept out of pots by covering the soil surface with something sharp, like toothpicks, plastic forks with the handle in the soil & tines up, broken twigs - whatever's handy that would make it uncomfortable for a squirrel to get in there to dig around. It would be best to use something that won't inhibit the exchange of moisture & air, like covering the soil with rocks.

How about buying some cheap dollar store hot sauce or Tabasco. Dilute it with water in a sprayer and spray your plants. They would all smell like hot pepper. You could sprinkle ground red pepper on the ground around plants. Don't use pepper flakes unless you want odd pepper popping up all over.

These lil critters can be so destructive. In my squirrel and chipmunk invasion I soak small rags in ammonia and place in a container baggie or plastic container , poke some holes in them and place them in areas to keep the critters away. Or place the rags in the holes they dig in the ground, usually near new plantings. Some mint oil also works rub some on a pot or plant. Or adopt a outside cat they will patrol their territory and the critter issue is mute. That was the best solution. And didn't need to worry about them getting in the attic in winters. Since your dealing with a balcony just a house cat or dog will do.
I lost my kitty last fall. I never had any squirrel or chipmunk issue the whole time he was around. So peaceful. He did all the work and saved me time, hassle and money.

There's lot of YouTube videos . https://youtu.be/CQZyPjcQYlo